Science

GlyPerA™,
a Novel Antimicrobial Composition for
Prevention/ Prophylaxis of Viral, Bacterial or Fungal Infections

Presently, there is an immense demand to prevent spreading of microbial, especially viral infections in the population. Classical ways of the prevention are treatment of surfaces with antiseptic solutions, facial masks or vaccination. We suggest another preventive barrier for spreading of microbial infection: GlyPerA™, a formulation comprising hydrogen peroxide (H₂O₂) and glycine. It can be used for gargling of mouth or as a spray in the nasal cavity.

How it works?
Hydrogen peroxide is an established antiseptic that destroys bacteria, viruses and fungi. It is used: for disinfection of material surfaces (e.g. of medical instruments or devices) for sterilization of water and raw materials for food production (e.g. dairy products) as antimicrobial agent for vegetable/fruit skin treatment for disinfection of wounds

Although H₂O₂ is a GRAS (Generally regarded as safe) substance, amounts used for the applications mentioned above are strictly regulated because: H₂O₂ is a very strong oxidant. H₂O₂ is a member of chemically aggressive ROS (Reactive Oxygen Species) that are especially harmful for mitochondria, the powerhouse of the cell.

The cell has an elaborate defense system against the oxidative stress. Reduced glutathione (GSH; Tripeptide: γ-glutamyl-cysteinyl-glycine) is one of the most important scavengers of ROS. Namely, within the cell, reduced GSH inactivates hydrogen peroxide.

We very recently have discovered that glycolic acid, glyoxylic acid or the amino acid glycine can increase amounts of reduced GSH many fold and this way neutralize toxic effects of H₂O₂ within the cell.* Thus, H₂O₂ outside of cells kills bacteria and viruses, whereas glycine, another component o GlyPerA™ reduces GSH within the cell and this way neutralizes toxic effects of leaked H₂O₂.

Owner of KnowHow and related patent is Dzala LLC.